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Publications 2007
The Chemopreventive Polyphenol Curcumin Prevents Hematogenous Breast Cancer Metastases in Immunodeficient Mice Through Induction of Apoptosis and Inhibition of NFkB/AP-1/CRE Dependent Transcription of Matrix Metalloproteases. Cellular and Physiological Biochemistry, in press, 19, 137-52, 2007.
Computational methods for protein fold prediction: an ab-initio topological approach. In: Data Mining in Biomedicine. (Eds. Pardalos PM, Boginski VL, Vazacopoulos A) Vol. 7, 2007, Springer-Verlag. SBN 978-0-387-69318-7. Pagg. 391-430.
Evaluation of the structural quality of modeled proteins by using globularity criteria BMC Structural Biology, accepted.
Identification of phosphoproteins and determination of phosphorylation sites by zirconium dioxide enrichment and SELDI-MS/MS J. Mass Spectrom. Manuscript (submitted)
A MicroRNA Signature of Hypoxia. Mol Cell Biol, 2007 (in press).
Identification of genes selectively regulated by interferons in endothelial cells. J. Immunol., 178, 1122-35, 2007
New computational strategy to analyze the interactions of ERalpha and ERbeta with different ERE sequences. J Comput Chem. 2007 Jan 31; [Epub ahead of print]. PMID: 17269124
Immunocell-array for molecular dissection of multiple signaling pathways in mammalian cells. Mol Cell Proteomics 2007 (in press)
Trop-1 are conserved growth stimulatory molecules that mark early stages of tumor progression. Cancer 2007 (in press). 2006
Molecular subtyping of breast cancer from traditional tumor marker profiles using parallel clustering methods. Clin Cancer Res 2006 12(3):781-90.
TEF-1 and C/EBP. are major p38. MAP kinase-regulated transcription factors in proliferating cardiomyocytes. Biochemical J. 396: 163-172, 2006
Microarray Expression Profiles of Angiogenesis-Related Genes Predict Tumor Cell Response to Artemisinins. The Pharmacogenomics J., 2006, 6, 269-278
Lipoic acid activates anti oxidative stress responses in endothelial cells up-regulating Thioredoxin reductase 1 and modulating angiogenesis. Carcinogenesis, 2006, Nov 24 [Epub ahead of print]
PLC-.2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays. Int J Oncol 2006 Apr;28(4):863-72.
The forgotten variables of DNA array hybridization. Trends Biotech. 24 (10): 443-448 (2006).
Proteomic analysis of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of retinoblastoma-interacting-zinc-finger protein. J. Proteome Res. 5: 1176-1185, 2006.
The dynamics of estrogen recepor activity Maturitas 54: 315-320, 2006
Amino acid propensities for secondary structures are influenced by the protein structural class. Biochem Biophys Res Commun. 2006 Apr 7;342(2):441-51.
La predizione della struttura delle proteine. Compositi e Nanotecnologie, 2006, 2, 43-47.
Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation. Exp Cell Res. 2006 Feb 1;312(3):340-9. Epub 2005 Dec 13.
Proteomic analysis of MCF-7 breast cancer cell line exposed to mitogenic concentration of 17 .-estradiol. Proteomics. 2006 Nov;6(22):5973-82.
Hystone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006 6(1): 38-51.
Bioinformatics tools for the analysis of gene expression by microarrays. Recent Devel. Nucleic Acid Res., 2(2006): 175-200
Gene expression analysis by integration of microarrays technology, bioinformatics tools and biocomputing methods. Compositi e Nanotecnologie, 2 (2006), 13-18.
The AP-2. Transcription Factor Regulates Tumor Cell Migration and Apoptosis. Advances in Molecular Oncology, in press.
Molecular imaging: a new way to stduy molecular processes in vivo Molecular and Cellular Endocrinology 246:69-75, 2006
Genistein affect adipose tissue depositino in a dose-dependent and gender-specific manner Endocrinology 2006, 147:5740-51
Axillary Lymph Node Nanometastases Are Prognostic Factors for Disease-Free Survival and Metastatic Relapse in Breast Cancer Patients. Clinical Cancer Res 12(22), 6696-6701, 2006,.
Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem., 2006, 98: 1163-1184.
Changes of topoisomerase IIalpha expression in breast tumors after neoadjuvant chemotherapy predicts relapse-free survival. Clin Cancer Res. 12(5):1501-6 (2006).
A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A, 103: 2257-2261, 2006. 2005
A Combinatorial Approach to Gene Expression Analysis: DNA Microarrays. In: Combinatorial Chemistry and Technology, Principles, Methods and Applications, 2nd ed. (Eds. Miertus, S., Fassina, G.), Marcel Dekker, New York, pp. 539-565, 2005. (Full text) Immune prevention of mammary carcinogenesis in HER-2/neu transgenic mice: a microarray Scenario. Cancer Immunology Immunotherapy, 54, 599-610. 2005. (PubMed link) Transcriptional Control of Cell Density Dependent Regulation of Matrix Metalloproteinase and TIMP Expression in Breast Cancer Cell Lines. Thrombosis and Haemostasis 93, 761-769, 2005. (PubMed link)
An integrated approach of immunogenomics and bioinformatics to identify new Tumor Associated Antigens (TAA) for mammary cancer immunological prevention. BMC Bioinformatics 2005 6(Suppl 4):S7 doi:10.1186/1471-2105-6-S4-S7. (PubMed link) (Full text)
miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A, 102: 13944-13949, 2005.
Transglutaminases and their substrates. Prog Exp Tumor Res., 38, 37-57. 2005. (PubMed link)
The TGF-beta family members BMP-2 and MIC-1 as mediators of the anti-angiogenic activity of 4-Hydroxyphenylretinamide. Clinical Cancer Research 11: 4610-4619, 2005 (PubMed link)
MicroRNA gene expression deregulation in human breast cancer. Cancer Res, 65: 7065-7070, 2005.
Homology modelling studies on human galactose-1-phosphate uridylyltransferase and on its galactosemia-related mutant Q188R provide an explanation of molecular effects of the mutation on homo- and heterodimers. J. Med. Chem., 48, 773-779. 2005. (PubMed link)
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukaemia cells. Nat. Medicine 11: 77-84, 2005. (PubMed link)
Molecular Mechanisms of Angiopreventive Compounds: Microarray Gene Expression Analyses. Mutation Research Fund. Mol. M. 591, 198-211, 2005 (PubMed link)
Review of: The Inhibitor of Cyclin-Dependent Kinase 4a/Alternative Reading Frame (INK4a/ARF) Locus Encoded Proteins p16INK4a and p19ARF Repress Cyclin D1 Transcription through Distinct cis Elements. Breast Cancer Online (http://www.bco.org) 8(2). 2005. (Full text)
New insights on estrogen action from gene expression profiling. In: Signal Transduction and Neoplastic Transformation in Endocrine Systems: Molecular mechanisms and clinical aspects (Eds. G. Vecchio et al.) Accademia dei Lincei Press, 2005. (Full text)
A conserved growth-stimulatory role of the Trop1 genes in transformed cells in mouse and man. Eur. J. Cancer. 2005. In press. 2004
A computational search for box C/D snoRNA genes in the D. melanogaster genome. Bioinformatics 20, 3293-3301 (2004) (PubMed link)
Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression. Cancer Res. 64: 5154-5161. 2004. (PubMed link)
Towards a long-lasting immune prevention of HER2 mammary carcinomas: directions from transgenic mice. Cell Cycle 3:704-706, 2004 (PubMed link)
Estrogens promote persistent G1 activation of the CCND1 gene by inducing transcriptional de-repression via c-Jun/c-Fos/ER complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter. Mol. Cell. Biol. 24: 7260-7274, 2004. (PubMed link)
The gene expression program activated by estrogen in hormone-responsive human breast cancer cells. J. Mol. Endocrinol. 32: 719-775, 2004 ( PubMed link)
Putative Estrogen-Responsive Genes database (PERG). Proceedings of BITS (Bioinformatics Italian Society Meeting), 2004 (Abstract)
Altered Epigenetic Signals in Human Disease. Cancer Biol. Ther. Sep 23;3(9). 2004 [Epub ahead of print] (PubMed link)
RRE: a tool for the extraction of non-coding regions surrounding annotated genes from genomic datasets. Bioinformatics. 20,2848-2850. 2004. (PubMed link)
An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci U S A, 101: 9740-9744, 2004. (PubMed link)
A proteomic approach for the study of estrogen regulation in ZR 75.1 breast cancer cell line. International Symposium on Molecular Profiling, Cosenza, Jan. 2004 (Abstract)
Comparative analysis of the oestrogen-responsive gene expression profile of breast cancer cells with three different microarray platforms. useR!, 20-22 May 2004, Vienna, Austria. (Abstract)
Comparative analysis with three different microarray platforms of the estrogen-responsive transcriptome from breast cancer cells. Proceedings of BITS 2004 (Bioinformatics Italian Society Meeting 2004). (Abstract)
Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha. Clin. Cancer Res. 10: 402-409, 2004 (PubMed link)
Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions. J Clin Invest. 113, 709-717. 2004. (PubMed link)
The Zn finger domain of RIZ protein promotes MCF-7 cell proliferation. Cancer Lett. 215: 229-237. 2004. (PubMed link)
Microarray data analysis and mining. In Methods in Molecular Medicine: Molecular diagnosis of infectious diseases. Pg 67-90 Humana Press, Inc. Totowa MA, Editors: J. Decker and U. Reischl. 2004.
Microarray analysis of the estrogen-regulated transcriptome as a new tool for breast cancer prognosis and prediction of treatment response. 2nd World Congress of Gynecological Endocrinology, Florence (Italy). Gynecol. Endocrinol. 18 (Suppl. 1): p. 183, 2004 (Abstract) (Slide show: http://www.lorenzinifoundation.org/menopause2004/slide/)
Molecular mechanisms of female sex steroid hormone action on proliferation. 5th International Symposium "Women's Health and Menopause", Florence (Italy), 2004 (Abstract)
Molecular identification of ERalpha-positive breast cancer cells by the expression profile of an intrinsic set of estrogen regulated genes. J. Cell. Physiol. 200: 440-450, 2004 ( PubMed link) 2003
Molecular characterization of breast cancer aggressiveness. Int. J. Biol. Markers 18: 36-39, 2003 (PubMed link)
Distinct signalling pathways mediate stimulation of cell cycle progression and prevention of apoptosis by estrogen in rat pituitary tumor cells. Mol. Biol. Cell. 14: 5051-5059, 2003 (PubMed link)
Analysis of the estrogen-responsive transcriptome from breast cancer cells: a comparative analysis with three different microarray platforms. Proceedings of the NETTAB 2003 Workshop: 'Bioinformatics for the management, analysis and interpretation of microarray data' (Eds. Marabotti A, Facchiano A, Romano P.), pp. 73-77, 2003 (Abstract)
Alternative splicing of the human estrogen receptor alpha primary transcript: mechanisms of exon skipping. Int. J. Mol. Med. 12: 355-363, 2003 (PubMed link)
Identification of genes involved in growth inhibition of breast cancer cells transduced with estrogen receptor. FEBS Lett. 553: 445-450, 2003 (PubMed link)
A proteomic approach for the study of estrogen regulation in ZR 75.1 breast cancer cell line. "I Congresso Nazionale IHUPO" (Sezione Italiana Human Proteome Organization), Napoli, 26-27 September 2003 (Abstract)
Estrogeni e carcinoma mammario: un approccio di proteomica. XXI Congresso della Società Chimica Italiana, Torino 22-27 Giugno 2003 (Abstract)
A proteomic approach for the study of estrogen regulation in ZR 75.1 breast cancer cell line. 16th International Mass Spectrometry Conference, Edimburgo, Sept. 2003 (Abstract)
The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene. Proc Natl Acad Sci U S A 100: 11517-11522, 2003 (PubMed link)
A bioinformatic workbech for the analysis of microarray data based on open source software and public databases. Proceedings of the NETTAB 2003 Workshop: 'Bioinformatics for the management, analysis and interpretation of microarray data' (Eds. Marabotti A, Facchiano A, Romano, P.), pp. 73-77, 2003 (Abstract)
Re: Microarray studies challenge theories of metastasis. J. Natl Cancer Inst. 95: 829, 2003 (PubMed link)
Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival. Int. J. Cancer 103: 466-474, 2003 (PubMed link)
Quantitative real-time RT-PCR analysis of eight novel estrogen-regulated genes in breast cancer. Int J Biol Markers. 18: 123-129, 2003 (PubMed link)
Estrogen Control of Hormone-responsive Breast Cancer Cell Growth and Functions. Risk Factors of Breast Cancer - EU COST Action B20 on Mammary Development, Function and Cancer, Montpellier (France), 2003 (Abstract) 2002
Loss of methylation at chromosome 11p15.5 is common in human adult tumors. Oncogene 21: 2564-2572, 2002 (PubMed link) 2001
Gene expression monitoring in hormone-responsive human breast cancer cells during estrogen-induced cell cycle progression. Nature Genetics "Oncogenomics Conference - Dissecting cancer through genome research". January 25-27, 2001, Tucson, Arizona, USA. Abstract
Internet tools for the analysis of gene expression by data bases integration. Proceedings of the NETTAB 2001 Workshop: 'CORBA and XML: Toward a bioinformatics integrated network environment' (Eds. Iannotta B, Malusa F, Marra D, Romano, P.), pp. 99-101, 2001. (Abstract) |
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